Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
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Experiments
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[Homology]
Score
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)    
Predicted Functional Partners:
TGFBR2
TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]
    
 0.999
LTBP1
Latent transforming growth factor beta binding protein 1.
    
 0.998
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
    
 0.997
DCN
Decorin; May affect the rate of fibrils formation.
    
 0.989
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
    
0.988
LRRC32
Leucine rich repeat containing 32.
    
 0.987
NRROS
Negative regulator of reactive oxygen species.
    
 0.974
TGFBR3
Transforming growth factor beta receptor 3.
    
 0.959
LTBP3
Uncharacterized protein.
    
 0.949
TGFB3
Transforming growth factor beta; Belongs to the TGF-beta family.
     
0.949
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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