Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PLK4Polo like kinase 4. (970 aa)    
Predicted Functional Partners:
CEP152
Centrosomal protein 152.
   
 0.991
STIL
STIL centriolar assembly protein.
   
 0.960
CENPJ
Centromere protein J.
   
 0.943
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.924
PLK1
Serine/threonine-protein kinase PLK.
   
 0.903
ENSNLEP00000046801
Protein kinase domain-containing protein.
   
 0.903
SASS6
SAS-6 centriolar assembly protein.
   
 0.898
CCNA2
Cyclin A2; Belongs to the cyclin family.
   
 
 0.888
PBK
PDZ binding kinase.
   
 
 0.888
AURKB
Uncharacterized protein.
   
 0.887
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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