| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC45 | CDC6 | ENSNLEP00000033088 | ENSNLEP00000002132 | Cell division cycle 45. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.947 |
| CDC45 | CDT1 | ENSNLEP00000033088 | ENSNLEP00000018929 | Cell division cycle 45. | Chromatin licensing and DNA replication factor 1. | 0.962 |
| CDC45 | MCM2 | ENSNLEP00000033088 | ENSNLEP00000017168 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.996 |
| CDC45 | MCM3 | ENSNLEP00000033088 | ENSNLEP00000004678 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.987 |
| CDC45 | MCM4 | ENSNLEP00000033088 | ENSNLEP00000016189 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.994 |
| CDC45 | MCM5 | ENSNLEP00000033088 | ENSNLEP00000033607 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.989 |
| CDC45 | MCM6 | ENSNLEP00000033088 | ENSNLEP00000010722 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.995 |
| CDC45 | MCM7 | ENSNLEP00000033088 | ENSNLEP00000013974 | Cell division cycle 45. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.995 |
| CDC45 | ORC1 | ENSNLEP00000033088 | ENSNLEP00000021868 | Cell division cycle 45. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.988 |
| CDC45 | ORC2 | ENSNLEP00000033088 | ENSNLEP00000008459 | Cell division cycle 45. | Origin recognition complex subunit 2. | 0.961 |
| CDC6 | CDC45 | ENSNLEP00000002132 | ENSNLEP00000033088 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Cell division cycle 45. | 0.947 |
| CDC6 | CDT1 | ENSNLEP00000002132 | ENSNLEP00000018929 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Chromatin licensing and DNA replication factor 1. | 0.999 |
| CDC6 | MCM2 | ENSNLEP00000002132 | ENSNLEP00000017168 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.992 |
| CDC6 | MCM3 | ENSNLEP00000002132 | ENSNLEP00000004678 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.996 |
| CDC6 | MCM4 | ENSNLEP00000002132 | ENSNLEP00000016189 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.989 |
| CDC6 | MCM5 | ENSNLEP00000002132 | ENSNLEP00000033607 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.961 |
| CDC6 | MCM6 | ENSNLEP00000002132 | ENSNLEP00000010722 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.990 |
| CDC6 | MCM7 | ENSNLEP00000002132 | ENSNLEP00000013974 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.997 |
| CDC6 | ORC1 | ENSNLEP00000002132 | ENSNLEP00000021868 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.997 |
| CDC6 | ORC2 | ENSNLEP00000002132 | ENSNLEP00000008459 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 2. | 0.986 |
