Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2579 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
   
 0.998
ASH2L
ASH2 like, histone lysine methyltransferase complex subunit.
    
 0.934
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
    
 0.929
CHD7
Chromodomain helicase DNA binding protein 7.
   
 
 0.927
WDR5
WD_REPEATS_REGION domain-containing protein.
    
 0.877
BRD4
Bromodomain containing 4.
   
 
 0.831
CHD9
Chromodomain helicase DNA binding protein 9.
   
    0.808
ENSNLEP00000029307
Uncharacterized protein.
   
    0.808
ADNP
Activity dependent neuroprotector homeobox.
   
 
 0.806
WDR5B
WD repeat domain 5B.
    
 0.778
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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