STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAK4Non-specific serine/threonine protein kinase. (595 aa)    
Predicted Functional Partners:
CDC42
Cell division cycle 42.
   
 0.996
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
    
 0.973
NCK1
Cytoplasmic protein.
    
 0.959
NCK2
Cytoplasmic protein.
    
 0.957
RAC2
Rac family small GTPase 2.
   
 0.955
LIMK2
LIM domain kinase 2.
    
0.953
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
0.945
ROBO1
Roundabout guidance receptor 1.
   
 0.936
GNG12
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
     
  0.929
RAC3
Rac family small GTPase 3.
   
 0.928
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: medium (70%) [HD]