Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PCSK9Proprotein convertase subtilisin/kexin type 9. (693 aa)    
Predicted Functional Partners:
LDLR
Uncharacterized protein.
    
 0.987
VLDLR
Very low density lipoprotein receptor.
    
 0.968
LRP8
LDL receptor related protein 8.
    
 0.880
PCSK2
Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.
      
 0.844
USP24
Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family.
      
 0.832
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    
 0.825
PCSK1
Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.
      
 0.815
PCSK7
Proprotein convertase subtilisin/kexin type 7.
      
 0.812
PCSK5
Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family.
      
 0.773
SPTLC1
Serine palmitoyltransferase long chain base subunit 1.
   
 
 0.754
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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