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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHOC2SHOC2 leucine rich repeat scaffold protein. (582 aa)    
Predicted Functional Partners:
MRAS
Muscle RAS oncogene homolog.
    
 0.997
HRAS
HRas proto-oncogene, GTPase.
   
 0.976
PPP1CC
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
 0.975
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
 
  
 0.973
NRAS
NRAS proto-oncogene, GTPase.
   
 0.973
KRAS
KRAS proto-oncogene, GTPase.
   
 0.971
PPP1CA
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
 0.951
RRAS2
RAS related 2.
    
 0.950
PPP1CB
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 0.896
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
 
  
 0.734
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.