| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf112 | RAD51 | ENSNLEP00000018314 | ENSNLEP00000037495 | Chromosome 1 open reading frame 112. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.736 |
| C1orf112 | SPAST | ENSNLEP00000018314 | ENSNLEP00000018962 | Chromosome 1 open reading frame 112. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.858 |
| CHMP1A | IST1 | ENSNLEP00000036525 | ENSNLEP00000025984 | Charged multivesicular body protein 1A. | IST1 factor associated with ESCRT-III. | 0.914 |
| CHMP1A | SPAST | ENSNLEP00000036525 | ENSNLEP00000018962 | Charged multivesicular body protein 1A. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.866 |
| IST1 | CHMP1A | ENSNLEP00000025984 | ENSNLEP00000036525 | IST1 factor associated with ESCRT-III. | Charged multivesicular body protein 1A. | 0.914 |
| IST1 | SPAST | ENSNLEP00000025984 | ENSNLEP00000018962 | IST1 factor associated with ESCRT-III. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.984 |
| NUP107 | NUP133 | ENSNLEP00000004509 | ENSNLEP00000017555 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | Nucleoporin 133. | 0.999 |
| NUP107 | NUP43 | ENSNLEP00000004509 | ENSNLEP00000028289 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | Nucleoporin 43. | 0.999 |
| NUP107 | NUP85 | ENSNLEP00000004509 | ENSNLEP00000035250 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). | 0.999 |
| NUP107 | NUP98 | ENSNLEP00000004509 | ENSNLEP00000035244 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | Nucleoporin 98. | 0.999 |
| NUP107 | SPAST | ENSNLEP00000004509 | ENSNLEP00000018962 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.925 |
| NUP133 | NUP107 | ENSNLEP00000017555 | ENSNLEP00000004509 | Nucleoporin 133. | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | 0.999 |
| NUP133 | NUP43 | ENSNLEP00000017555 | ENSNLEP00000028289 | Nucleoporin 133. | Nucleoporin 43. | 0.999 |
| NUP133 | NUP85 | ENSNLEP00000017555 | ENSNLEP00000035250 | Nucleoporin 133. | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). | 0.999 |
| NUP133 | NUP98 | ENSNLEP00000017555 | ENSNLEP00000035244 | Nucleoporin 133. | Nucleoporin 98. | 0.999 |
| NUP133 | RAD51 | ENSNLEP00000017555 | ENSNLEP00000037495 | Nucleoporin 133. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.489 |
| NUP133 | SPAST | ENSNLEP00000017555 | ENSNLEP00000018962 | Nucleoporin 133. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.925 |
| NUP43 | NUP107 | ENSNLEP00000028289 | ENSNLEP00000004509 | Nucleoporin 43. | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). | 0.999 |
| NUP43 | NUP133 | ENSNLEP00000028289 | ENSNLEP00000017555 | Nucleoporin 43. | Nucleoporin 133. | 0.999 |
| NUP43 | NUP85 | ENSNLEP00000028289 | ENSNLEP00000035250 | Nucleoporin 43. | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). | 0.999 |
