NADK2 protein (Nomascus leucogenys) - STRING interaction network

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NADK2

NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (442 aa)

Predicted Functional Partners:

NADK

0.951

NNT

0.934

NADSYN1

0.933

NMNAT3

0.921

NMNAT1

0.921

SIRT4

0.913

NUDT12

0.911

NMNAT2

0.911

SIRT5

0.906

SIRT3

0.904

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NADK	NADK2	ENSNLEP00000000161	ENSNLEP00000019482	Uncharacterized protein.	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	0.951
NADK	NADSYN1	ENSNLEP00000000161	ENSNLEP00000013084	Uncharacterized protein.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.952
NADK	NMNAT1	ENSNLEP00000000161	ENSNLEP00000011413	Uncharacterized protein.	Nicotinamide-nucleotide adenylyltransferase.	0.936
NADK	NMNAT2	ENSNLEP00000000161	ENSNLEP00000021889	Uncharacterized protein.	Nicotinamide nucleotide adenylyltransferase 2.	0.947
NADK	NMNAT3	ENSNLEP00000000161	ENSNLEP00000005408	Uncharacterized protein.	Nicotinamide-nucleotide adenylyltransferase.	0.944
NADK	NNT	ENSNLEP00000000161	ENSNLEP00000012842	Uncharacterized protein.	Nicotinamide nucleotide transhydrogenase.	0.961
NADK	NUDT12	ENSNLEP00000000161	ENSNLEP00000013595	Uncharacterized protein.	Nudix hydrolase 12.	0.915
NADK	SIRT3	ENSNLEP00000000161	ENSNLEP00000018956	Uncharacterized protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.915
NADK	SIRT4	ENSNLEP00000000161	ENSNLEP00000018942	Uncharacterized protein.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.915
NADK	SIRT5	ENSNLEP00000000161	ENSNLEP00000026965	Uncharacterized protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.920
NADK2	NADK	ENSNLEP00000019482	ENSNLEP00000000161	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Uncharacterized protein.	0.951
NADK2	NADSYN1	ENSNLEP00000019482	ENSNLEP00000013084	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.933
NADK2	NMNAT1	ENSNLEP00000019482	ENSNLEP00000011413	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide-nucleotide adenylyltransferase.	0.921
NADK2	NMNAT2	ENSNLEP00000019482	ENSNLEP00000021889	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide nucleotide adenylyltransferase 2.	0.911
NADK2	NMNAT3	ENSNLEP00000019482	ENSNLEP00000005408	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide-nucleotide adenylyltransferase.	0.921
NADK2	NNT	ENSNLEP00000019482	ENSNLEP00000012842	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nicotinamide nucleotide transhydrogenase.	0.934
NADK2	NUDT12	ENSNLEP00000019482	ENSNLEP00000013595	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	Nudix hydrolase 12.	0.911
NADK2	SIRT3	ENSNLEP00000019482	ENSNLEP00000018956	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.904
NADK2	SIRT4	ENSNLEP00000019482	ENSNLEP00000018942	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.913
NADK2	SIRT5	ENSNLEP00000019482	ENSNLEP00000026965	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.906

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