STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRF1Perforin 1. (513 aa)    
Predicted Functional Partners:
GNLY
Saposin B-type domain-containing protein.
   
  
 0.990
GZMA
Granzyme A; Belongs to the peptidase S1 family.
   
 0.963
NKG7
Natural killer cell granule protein 7.
   
  
 0.942
CD8A
CD8a molecule.
   
  
 0.926
FASLG
Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family.
   
 0.902
GZMH
Granzyme H; Belongs to the peptidase S1 family.
   
 0.897
IL2RB
Interleukin 2 receptor subunit beta.
   
  
 0.877
CD247
CD247 molecule.
   
  
 0.845
KLRK1
Killer cell lectin like receptor K1.
   
 0.760
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.748
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.