| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMT2 | C12orf66 | ENSNLEP00000013825 | ENSNLEP00000020737 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Chromosome 12 open reading frame 66. | 0.892 |
| BMT2 | DEPDC5 | ENSNLEP00000013825 | ENSNLEP00000005768 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing protein. | 0.872 |
| BMT2 | ENSNLEP00000033843 | ENSNLEP00000013825 | ENSNLEP00000033843 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Uncharacterized protein. | 0.802 |
| BMT2 | KPTN | ENSNLEP00000013825 | ENSNLEP00000003752 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Kaptin, actin binding protein. | 0.826 |
| BMT2 | MIOS | ENSNLEP00000013825 | ENSNLEP00000019574 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Meiosis regulator for oocyte development. | 0.409 |
| BMT2 | NPRL2 | ENSNLEP00000013825 | ENSNLEP00000008544 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR2 like, GATOR1 complex subunit. | 0.807 |
| BMT2 | NPRL3 | ENSNLEP00000013825 | ENSNLEP00000009719 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR3 like, GATOR1 complex subunit. | 0.814 |
| BMT2 | SZT2 | ENSNLEP00000013825 | ENSNLEP00000024360 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | SZT2 subunit of KICSTOR complex. | 0.544 |
| BMT2 | WDR24 | ENSNLEP00000013825 | ENSNLEP00000025805 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat domain 24. | 0.434 |
| BMT2 | WDR59 | ENSNLEP00000013825 | ENSNLEP00000015758 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat domain 59. | 0.432 |
| C12orf66 | BMT2 | ENSNLEP00000020737 | ENSNLEP00000013825 | Chromosome 12 open reading frame 66. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.892 |
| C12orf66 | DEPDC5 | ENSNLEP00000020737 | ENSNLEP00000005768 | Chromosome 12 open reading frame 66. | DEP domain-containing protein. | 0.996 |
| C12orf66 | ENSNLEP00000033843 | ENSNLEP00000020737 | ENSNLEP00000033843 | Chromosome 12 open reading frame 66. | Uncharacterized protein. | 0.999 |
| C12orf66 | KPTN | ENSNLEP00000020737 | ENSNLEP00000003752 | Chromosome 12 open reading frame 66. | Kaptin, actin binding protein. | 0.999 |
| C12orf66 | MIOS | ENSNLEP00000020737 | ENSNLEP00000019574 | Chromosome 12 open reading frame 66. | Meiosis regulator for oocyte development. | 0.759 |
| C12orf66 | NPRL2 | ENSNLEP00000020737 | ENSNLEP00000008544 | Chromosome 12 open reading frame 66. | NPR2 like, GATOR1 complex subunit. | 0.995 |
| C12orf66 | NPRL3 | ENSNLEP00000020737 | ENSNLEP00000009719 | Chromosome 12 open reading frame 66. | NPR3 like, GATOR1 complex subunit. | 0.764 |
| C12orf66 | SZT2 | ENSNLEP00000020737 | ENSNLEP00000024360 | Chromosome 12 open reading frame 66. | SZT2 subunit of KICSTOR complex. | 0.714 |
| C12orf66 | WDR24 | ENSNLEP00000020737 | ENSNLEP00000025805 | Chromosome 12 open reading frame 66. | WD repeat domain 24. | 0.995 |
| C12orf66 | WDR59 | ENSNLEP00000020737 | ENSNLEP00000015758 | Chromosome 12 open reading frame 66. | WD repeat domain 59. | 0.995 |