| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOB | ATP7A | ENSNLEP00000000795 | ENSNLEP00000001608 | Apolipoprotein B. | ATPase copper transporting alpha. | 0.575 |
| APOB | PPARA | ENSNLEP00000000795 | ENSNLEP00000019094 | Apolipoprotein B. | Peroxisome proliferator activated receptor alpha. | 0.558 |
| APOB | PPARG | ENSNLEP00000000795 | ENSNLEP00000037002 | Apolipoprotein B. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.486 |
| APOB | RXRA | ENSNLEP00000000795 | ENSNLEP00000036994 | Apolipoprotein B. | Uncharacterized protein. | 0.501 |
| APOB | UCP2 | ENSNLEP00000000795 | ENSNLEP00000020744 | Apolipoprotein B. | Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.603 |
| ATP7A | APOB | ENSNLEP00000001608 | ENSNLEP00000000795 | ATPase copper transporting alpha. | Apolipoprotein B. | 0.575 |
| ATP7A | PPARG | ENSNLEP00000001608 | ENSNLEP00000037002 | ATPase copper transporting alpha. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.533 |
| ATP7A | RXRA | ENSNLEP00000001608 | ENSNLEP00000036994 | ATPase copper transporting alpha. | Uncharacterized protein. | 0.545 |
| ATP7A | UCP2 | ENSNLEP00000001608 | ENSNLEP00000020744 | ATPase copper transporting alpha. | Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.604 |
| GPAT4 | LEPR | ENSNLEP00000034535 | ENSNLEP00000037858 | Glycerol-3-phosphate acyltransferase 4. | Leptin receptor. | 0.787 |
| GPAT4 | PCK1 | ENSNLEP00000034535 | ENSNLEP00000008607 | Glycerol-3-phosphate acyltransferase 4. | Phosphoenolpyruvate carboxykinase 1. | 0.682 |
| GPAT4 | PPARA | ENSNLEP00000034535 | ENSNLEP00000019094 | Glycerol-3-phosphate acyltransferase 4. | Peroxisome proliferator activated receptor alpha. | 0.788 |
| GPAT4 | UCP2 | ENSNLEP00000034535 | ENSNLEP00000020744 | Glycerol-3-phosphate acyltransferase 4. | Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.806 |
| LEP | LEPR | ENSNLEP00000014938 | ENSNLEP00000037858 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Leptin receptor. | 0.995 |
| LEP | PCK1 | ENSNLEP00000014938 | ENSNLEP00000008607 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Phosphoenolpyruvate carboxykinase 1. | 0.449 |
| LEP | PPARA | ENSNLEP00000014938 | ENSNLEP00000019094 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Peroxisome proliferator activated receptor alpha. | 0.584 |
| LEP | PPARG | ENSNLEP00000014938 | ENSNLEP00000037002 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.684 |
| LEP | PPARGC1A | ENSNLEP00000014938 | ENSNLEP00000041737 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | PPARG coactivator 1 alpha. | 0.625 |
| LEP | UCP2 | ENSNLEP00000014938 | ENSNLEP00000020744 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.616 |
| LEPR | GPAT4 | ENSNLEP00000037858 | ENSNLEP00000034535 | Leptin receptor. | Glycerol-3-phosphate acyltransferase 4. | 0.787 |
