STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTGS1Prostaglandin-endoperoxide synthase 1. (585 aa)    
Predicted Functional Partners:
TMEM86A
Transmembrane protein 86A.
      
 0.833
VIPR1
Vasoactive intestinal peptide receptor 1; Belongs to the G-protein coupled receptor 2 family.
      
 0.833
GET3
Arsenical pump-driving ATPase; Belongs to the arsA ATPase family.
      
 0.832
TSPAN2
Tetraspanin.
      
 0.792
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif 3.
   
  
 0.729
TBXAS1
Thromboxane A synthase 1; Belongs to the cytochrome P450 family.
   
  
 0.676
PLA2G4A
Phospholipase A2.
  
  
 0.630
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
  
 0.606
PTGIR
Prostaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.570
IL6
Uncharacterized protein.
   
  
 0.564
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.