Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CD44CD44 molecule (Indian blood group). (742 aa)    
Predicted Functional Partners:
SPP1
Secreted phosphoprotein 1.
   
 0.979
EGFR
Receptor protein-tyrosine kinase.
    
 
 0.912
SELL
L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
    
 0.905
ERBB2
Receptor protein-tyrosine kinase.
    
 
 0.893
SELE
Selectin E.
    
 0.889
MMP7
Matrix metallopeptidase 7.
    
 0.854
CD74
CD74 molecule.
    
 0.852
SELP
Selectin P.
    
 0.851
SRC
Tyrosine-protein kinase.
   
 
 0.819
IGFBP3
Insulin like growth factor binding protein 3.
    
 
 0.816
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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