| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD14 | TLR1 | ENSNLEP00000011329 | ENSNLEP00000020714 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.500 |
| CD14 | TLR2 | ENSNLEP00000011329 | ENSNLEP00000022789 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll-like receptor. | 0.978 |
| CD14 | TLR4 | ENSNLEP00000011329 | ENSNLEP00000025448 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.973 |
| CD14 | TLR6 | ENSNLEP00000011329 | ENSNLEP00000035326 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | TIR domain-containing protein. | 0.500 |
| MYD88 | NFKB1 | ENSNLEP00000006463 | ENSNLEP00000016247 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Nuclear factor kappa B subunit 1. | 0.875 |
| MYD88 | TICAM1 | ENSNLEP00000006463 | ENSNLEP00000016200 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.613 |
| MYD88 | TICAM2 | ENSNLEP00000006463 | ENSNLEP00000014309 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll like receptor adaptor molecule 2. | 0.460 |
| MYD88 | TIRAP | ENSNLEP00000006463 | ENSNLEP00000043926 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | TIR domain containing adaptor protein. | 0.997 |
| MYD88 | TLR1 | ENSNLEP00000006463 | ENSNLEP00000020714 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.984 |
| MYD88 | TLR2 | ENSNLEP00000006463 | ENSNLEP00000022789 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll-like receptor. | 0.990 |
| MYD88 | TLR4 | ENSNLEP00000006463 | ENSNLEP00000025448 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.997 |
| MYD88 | TLR6 | ENSNLEP00000006463 | ENSNLEP00000035326 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | TIR domain-containing protein. | 0.815 |
| MYD88 | TOLLIP | ENSNLEP00000006463 | ENSNLEP00000015942 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | Toll interacting protein. | 0.961 |
| NFKB1 | MYD88 | ENSNLEP00000016247 | ENSNLEP00000006463 | Nuclear factor kappa B subunit 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.875 |
| NFKB1 | TIRAP | ENSNLEP00000016247 | ENSNLEP00000043926 | Nuclear factor kappa B subunit 1. | TIR domain containing adaptor protein. | 0.414 |
| NFKB1 | TLR1 | ENSNLEP00000016247 | ENSNLEP00000020714 | Nuclear factor kappa B subunit 1. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.549 |
| NFKB1 | TLR2 | ENSNLEP00000016247 | ENSNLEP00000022789 | Nuclear factor kappa B subunit 1. | Toll-like receptor. | 0.970 |
| NFKB1 | TLR4 | ENSNLEP00000016247 | ENSNLEP00000025448 | Nuclear factor kappa B subunit 1. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.965 |
| NFKB1 | TLR6 | ENSNLEP00000016247 | ENSNLEP00000035326 | Nuclear factor kappa B subunit 1. | TIR domain-containing protein. | 0.460 |
| TICAM1 | MYD88 | ENSNLEP00000016200 | ENSNLEP00000006463 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.613 |
