Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FGFR3Receptor protein-tyrosine kinase. (583 aa)    
Predicted Functional Partners:
FGFR2
Fibroblast growth factor receptor.
   
 0.987
FGF1
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
    
 0.984
FGFR1
Fibroblast growth factor receptor.
   
 0.978
FGFR4
Fibroblast growth factor receptor.
   
 
 0.952
BLK
Tyrosine-protein kinase.
   
  0.945
FGF2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 0.942
FGF9
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.931
ICK
Intestinal cell kinase.
   
   0.929
MAK
Male germ cell associated kinase.
   
   0.929
CDK20
Cyclin dependent kinase 20.
   
    0.928
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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