| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BLM | FANCG | ENSNLEP00000014738 | ENSNLEP00000005687 | BLM RecQ like helicase. | FA complementation group G. | 0.958 |
| BLM | FANCM | ENSNLEP00000014738 | ENSNLEP00000048241 | BLM RecQ like helicase. | FA complementation group M. | 0.996 |
| BLM | RAD51 | ENSNLEP00000014738 | ENSNLEP00000037495 | BLM RecQ like helicase. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.988 |
| BLM | RMI1 | ENSNLEP00000014738 | ENSNLEP00000004369 | BLM RecQ like helicase. | RecQ mediated genome instability 1. | 0.998 |
| BLM | RMI2 | ENSNLEP00000014738 | ENSNLEP00000012384 | BLM RecQ like helicase. | RecQ mediated genome instability 2. | 0.999 |
| BLM | RPA1 | ENSNLEP00000014738 | ENSNLEP00000020837 | BLM RecQ like helicase. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.996 |
| BLM | RPA2 | ENSNLEP00000014738 | ENSNLEP00000011805 | BLM RecQ like helicase. | Replication protein A2. | 0.978 |
| BLM | RPA3 | ENSNLEP00000014738 | ENSNLEP00000043039 | BLM RecQ like helicase. | Replication protein A3. | 0.994 |
| BLM | TOP3A | ENSNLEP00000014738 | ENSNLEP00000031941 | BLM RecQ like helicase. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.999 |
| BLM | WRN | ENSNLEP00000014738 | ENSNLEP00000045895 | BLM RecQ like helicase. | WRN RecQ like helicase. | 0.610 |
| FANCG | BLM | ENSNLEP00000005687 | ENSNLEP00000014738 | FA complementation group G. | BLM RecQ like helicase. | 0.958 |
| FANCG | FANCM | ENSNLEP00000005687 | ENSNLEP00000048241 | FA complementation group G. | FA complementation group M. | 0.999 |
| FANCG | RAD51 | ENSNLEP00000005687 | ENSNLEP00000037495 | FA complementation group G. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.709 |
| FANCG | RPA1 | ENSNLEP00000005687 | ENSNLEP00000020837 | FA complementation group G. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.960 |
| FANCG | RPA3 | ENSNLEP00000005687 | ENSNLEP00000043039 | FA complementation group G. | Replication protein A3. | 0.479 |
| FANCG | TOP3A | ENSNLEP00000005687 | ENSNLEP00000031941 | FA complementation group G. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.958 |
| FANCG | WRN | ENSNLEP00000005687 | ENSNLEP00000045895 | FA complementation group G. | WRN RecQ like helicase. | 0.697 |
| FANCM | BLM | ENSNLEP00000048241 | ENSNLEP00000014738 | FA complementation group M. | BLM RecQ like helicase. | 0.996 |
| FANCM | FANCG | ENSNLEP00000048241 | ENSNLEP00000005687 | FA complementation group M. | FA complementation group G. | 0.999 |
| FANCM | RAD51 | ENSNLEP00000048241 | ENSNLEP00000037495 | FA complementation group M. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.901 |
