node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPB2 | F2 | ENSNLEP00000003148 | ENSNLEP00000017190 | Carboxypeptidase B2. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.789 |
CPB2 | F3 | ENSNLEP00000003148 | ENSNLEP00000013508 | Carboxypeptidase B2. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.537 |
CPB2 | F7 | ENSNLEP00000003148 | ENSNLEP00000000571 | Carboxypeptidase B2. | Coagulation factor VII. | 0.592 |
CPB2 | PLAT | ENSNLEP00000003148 | ENSNLEP00000028835 | Carboxypeptidase B2. | Plasminogen activator; Belongs to the peptidase S1 family. | 0.731 |
CPB2 | PROC | ENSNLEP00000003148 | ENSNLEP00000032013 | Carboxypeptidase B2. | Protein C, inactivator of coagulation factors Va and VIIIa; Belongs to the peptidase S1 family. | 0.669 |
CPB2 | PROCR | ENSNLEP00000003148 | ENSNLEP00000012430 | Carboxypeptidase B2. | Protein C receptor. | 0.541 |
CPB2 | TFPI | ENSNLEP00000003148 | ENSNLEP00000007920 | Carboxypeptidase B2. | Tissue factor pathway inhibitor. | 0.504 |
CPB2 | THBD | ENSNLEP00000003148 | ENSNLEP00000032572 | Carboxypeptidase B2. | Thrombomodulin. | 0.760 |
F2 | CPB2 | ENSNLEP00000017190 | ENSNLEP00000003148 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Carboxypeptidase B2. | 0.789 |
F2 | F2R | ENSNLEP00000017190 | ENSNLEP00000015317 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.979 |
F2 | F3 | ENSNLEP00000017190 | ENSNLEP00000013508 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.877 |
F2 | F7 | ENSNLEP00000017190 | ENSNLEP00000000571 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor VII. | 0.882 |
F2 | PLAT | ENSNLEP00000017190 | ENSNLEP00000028835 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Plasminogen activator; Belongs to the peptidase S1 family. | 0.459 |
F2 | PROC | ENSNLEP00000017190 | ENSNLEP00000032013 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Protein C, inactivator of coagulation factors Va and VIIIa; Belongs to the peptidase S1 family. | 0.985 |
F2 | PROCR | ENSNLEP00000017190 | ENSNLEP00000012430 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Protein C receptor. | 0.675 |
F2 | TFPI | ENSNLEP00000017190 | ENSNLEP00000007920 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Tissue factor pathway inhibitor. | 0.794 |
F2 | THBD | ENSNLEP00000017190 | ENSNLEP00000032572 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Thrombomodulin. | 0.988 |
F2R | F2 | ENSNLEP00000015317 | ENSNLEP00000017190 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.979 |
F2R | F3 | ENSNLEP00000015317 | ENSNLEP00000013508 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.630 |
F2R | F7 | ENSNLEP00000015317 | ENSNLEP00000000571 | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. | Coagulation factor VII. | 0.472 |