Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)    
Predicted Functional Partners:
TGFBR2
TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]
   
0.999
SMURF2
E3 ubiquitin-protein ligase.
    
 0.999
SMAD7
Mothers against decapentaplegic homolog.
    
 0.999
SMAD2
Mothers against decapentaplegic homolog.
   
 0.998
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.997
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.997
SMAD3
Mothers against decapentaplegic homolog.
   
 0.996
SMAD4
Mothers against decapentaplegic homolog.
    
 0.993
SMURF1
E3 ubiquitin-protein ligase.
    
 0.991
TGFB3
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.989
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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