| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APIP | APRT | ENSNLEP00000030645 | ENSNLEP00000018947 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Adenine phosphoribosyltransferase. | 0.447 |
| APIP | MRI1 | ENSNLEP00000030645 | ENSNLEP00000015925 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.984 |
| APIP | MTAP | ENSNLEP00000030645 | ENSNLEP00000044217 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.603 |
| APRT | APIP | ENSNLEP00000018947 | ENSNLEP00000030645 | Adenine phosphoribosyltransferase. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.447 |
| APRT | LACC1 | ENSNLEP00000018947 | ENSNLEP00000002318 | Adenine phosphoribosyltransferase. | Uncharacterized protein. | 0.921 |
| APRT | MRI1 | ENSNLEP00000018947 | ENSNLEP00000015925 | Adenine phosphoribosyltransferase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.489 |
| APRT | MTAP | ENSNLEP00000018947 | ENSNLEP00000044217 | Adenine phosphoribosyltransferase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.817 |
| APRT | NT5E | ENSNLEP00000018947 | ENSNLEP00000015555 | Adenine phosphoribosyltransferase. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.936 |
| APRT | UPP1 | ENSNLEP00000018947 | ENSNLEP00000005553 | Adenine phosphoribosyltransferase. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.681 |
| APRT | UPP2 | ENSNLEP00000018947 | ENSNLEP00000001005 | Adenine phosphoribosyltransferase. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.736 |
| EPHX2 | MTAP | ENSNLEP00000019844 | ENSNLEP00000044217 | Epoxide hydrolase 2. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.845 |
| EPHX2 | NT5E | ENSNLEP00000019844 | ENSNLEP00000015555 | Epoxide hydrolase 2. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.684 |
| LACC1 | APRT | ENSNLEP00000002318 | ENSNLEP00000018947 | Uncharacterized protein. | Adenine phosphoribosyltransferase. | 0.921 |
| LACC1 | MRI1 | ENSNLEP00000002318 | ENSNLEP00000015925 | Uncharacterized protein. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.903 |
| LACC1 | MTAP | ENSNLEP00000002318 | ENSNLEP00000044217 | Uncharacterized protein. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.914 |
| LACC1 | NT5E | ENSNLEP00000002318 | ENSNLEP00000015555 | Uncharacterized protein. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.900 |
| LACC1 | SMS | ENSNLEP00000002318 | ENSNLEP00000012153 | Uncharacterized protein. | Spermine synthase. | 0.900 |
| LACC1 | SRM | ENSNLEP00000002318 | ENSNLEP00000011596 | Uncharacterized protein. | PABS domain-containing protein; Belongs to the spermidine/spermine synthase family. | 0.900 |
| MRI1 | APIP | ENSNLEP00000015925 | ENSNLEP00000030645 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.984 |
| MRI1 | APRT | ENSNLEP00000015925 | ENSNLEP00000018947 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Adenine phosphoribosyltransferase. | 0.489 |
