IL6 protein (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

IL6

Uncharacterized protein. (258 aa)

Predicted Functional Partners:

IL6R

0.999

NFKB1

0.991

RELA

0.984

JAK1

0.981

JAK2

0.975

IL6ST

0.969

STAT3

0.957

CNTFR

0.917

IFNG

0.915

TYK2

0.915

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNTFR	IL6	ENSNLEP00000005935	ENSNLEP00000047139	Ciliary neurotrophic factor receptor.	Uncharacterized protein.	0.917
CNTFR	IL6R	ENSNLEP00000005935	ENSNLEP00000035711	Ciliary neurotrophic factor receptor.	Interleukin 6 receptor.	0.402
CNTFR	IL6ST	ENSNLEP00000005935	ENSNLEP00000002648	Ciliary neurotrophic factor receptor.	Interleukin 6 signal transducer.	0.907
CNTFR	JAK1	ENSNLEP00000005935	ENSNLEP00000018412	Ciliary neurotrophic factor receptor.	Tyrosine-protein kinase.	0.903
CNTFR	JAK2	ENSNLEP00000005935	ENSNLEP00000010932	Ciliary neurotrophic factor receptor.	Tyrosine-protein kinase.	0.919
CNTFR	STAT3	ENSNLEP00000005935	ENSNLEP00000014018	Ciliary neurotrophic factor receptor.	Signal transducer and activator of transcription.	0.832
CNTFR	TYK2	ENSNLEP00000005935	ENSNLEP00000014804	Ciliary neurotrophic factor receptor.	Tyrosine-protein kinase.	0.893
IFNG	IL6	ENSNLEP00000004233	ENSNLEP00000047139	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Uncharacterized protein.	0.915
IFNG	IL6R	ENSNLEP00000004233	ENSNLEP00000035711	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin 6 receptor.	0.829
IFNG	IL6ST	ENSNLEP00000004233	ENSNLEP00000002648	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin 6 signal transducer.	0.733
IFNG	JAK1	ENSNLEP00000004233	ENSNLEP00000018412	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.977
IFNG	JAK2	ENSNLEP00000004233	ENSNLEP00000010932	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.977
IFNG	NFKB1	ENSNLEP00000004233	ENSNLEP00000016247	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Nuclear factor kappa B subunit 1.	0.722
IFNG	STAT3	ENSNLEP00000004233	ENSNLEP00000014018	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Signal transducer and activator of transcription.	0.819
IFNG	TYK2	ENSNLEP00000004233	ENSNLEP00000014804	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.683
IL6	CNTFR	ENSNLEP00000047139	ENSNLEP00000005935	Uncharacterized protein.	Ciliary neurotrophic factor receptor.	0.917
IL6	IFNG	ENSNLEP00000047139	ENSNLEP00000004233	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.915
IL6	IL6R	ENSNLEP00000047139	ENSNLEP00000035711	Uncharacterized protein.	Interleukin 6 receptor.	0.999
IL6	IL6ST	ENSNLEP00000047139	ENSNLEP00000002648	Uncharacterized protein.	Interleukin 6 signal transducer.	0.969
IL6	JAK1	ENSNLEP00000047139	ENSNLEP00000018412	Uncharacterized protein.	Tyrosine-protein kinase.	0.981

page 1 of 5

Server load: low (18%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About