| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEX52100.1 | EEX53775.1 | HMPREF6745_2381 | HMPREF6745_0889 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | Ser/Thr phosphatase family protein; COG: COG0737; Pfam: PF00149; InterPro: IPR006179. | 0.715 |
| EEX52100.1 | cinA | HMPREF6745_2381 | HMPREF6745_2601 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | 0.759 |
| EEX52100.1 | cpdB | HMPREF6745_2381 | HMPREF6745_2140 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.715 |
| EEX52100.1 | nadD | HMPREF6745_2381 | HMPREF6745_0581 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.748 |
| EEX52100.1 | nadE | HMPREF6745_2381 | HMPREF6745_2975 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.455 |
| EEX52100.1 | nudC | HMPREF6745_2381 | HMPREF6745_2139 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | Hydrolase, NUDIX family; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. | 0.704 |
| EEX52100.1 | pncB | HMPREF6745_2381 | HMPREF6745_1462 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.734 |
| EEX52100.1 | surE | HMPREF6745_2381 | HMPREF6745_1880 | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.759 |
| EEX53775.1 | EEX52100.1 | HMPREF6745_0889 | HMPREF6745_2381 | Ser/Thr phosphatase family protein; COG: COG0737; Pfam: PF00149; InterPro: IPR006179. | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | 0.715 |
| EEX53775.1 | cinA | HMPREF6745_0889 | HMPREF6745_2601 | Ser/Thr phosphatase family protein; COG: COG0737; Pfam: PF00149; InterPro: IPR006179. | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | 0.805 |
| EEX53775.1 | cpdB | HMPREF6745_0889 | HMPREF6745_2140 | Ser/Thr phosphatase family protein; COG: COG0737; Pfam: PF00149; InterPro: IPR006179. | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.844 |
| EEX53775.1 | nudC | HMPREF6745_0889 | HMPREF6745_2139 | Ser/Thr phosphatase family protein; COG: COG0737; Pfam: PF00149; InterPro: IPR006179. | Hydrolase, NUDIX family; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. | 0.793 |
| EEX53775.1 | surE | HMPREF6745_0889 | HMPREF6745_1880 | Ser/Thr phosphatase family protein; COG: COG0737; Pfam: PF00149; InterPro: IPR006179. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.802 |
| cinA | EEX52100.1 | HMPREF6745_2601 | HMPREF6745_2381 | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | HAD hydrolase, family IA, variant 1; Pfam: PF00702; InterPro: IPR005834. | 0.759 |
| cinA | EEX53775.1 | HMPREF6745_2601 | HMPREF6745_0889 | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | Ser/Thr phosphatase family protein; COG: COG0737; Pfam: PF00149; InterPro: IPR006179. | 0.805 |
| cinA | cobB | HMPREF6745_2601 | HMPREF6745_1136 | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | Transcriptional regulator, Sir2 family; COG: COG0846; Pfam: PF02146; InterPro: IPR003000; Belongs to the sirtuin family. Class III subfamily. | 0.625 |
| cinA | cpdB | HMPREF6745_2601 | HMPREF6745_2140 | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | 5'-nucleotidase, C-terminal domain protein; COG: COG0737; Pfam: PF00149,PF02872; InterPro: IPR006179; Belongs to the 5'-nucleotidase family. | 0.596 |
| cinA | nadD | HMPREF6745_2601 | HMPREF6745_0581 | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.919 |
| cinA | nadE | HMPREF6745_2601 | HMPREF6745_2975 | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.894 |
| cinA | nudC | HMPREF6745_2601 | HMPREF6745_2139 | Competence/damage-inducible domain protein CinA; COG: COG1546; Pfam: PF02464; InterPro: IPR008136; Belongs to the CinA family. | Hydrolase, NUDIX family; COG: COG2816; Pfam: PF09296,PF09297,PF00293; InterPro: IPR000086; Belongs to the Nudix hydrolase family. | 0.806 |