node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEX51876.1 | dnaJ | HMPREF6745_2647 | HMPREF6745_2649 | ABC transporter, ATP-binding protein; COG: COG0488; Pfam: PF00005; InterPro: IPR003439. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.715 |
EEX51876.1 | folC | HMPREF6745_2647 | HMPREF6745_2650 | ABC transporter, ATP-binding protein; COG: COG0488; Pfam: PF00005; InterPro: IPR003439. | Bifunctional protein FolC; COG: COG0285; Pfam: PF08245; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family. | 0.686 |
EEX51876.1 | galM2 | HMPREF6745_2647 | HMPREF6745_2651 | ABC transporter, ATP-binding protein; COG: COG0488; Pfam: PF00005; InterPro: IPR003439. | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. | 0.563 |
EEX51876.1 | glyA | HMPREF6745_2647 | HMPREF6745_2608 | ABC transporter, ATP-binding protein; COG: COG0488; Pfam: PF00005; InterPro: IPR003439. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.438 |
EEX51876.1 | grpE | HMPREF6745_2647 | HMPREF6745_2648 | ABC transporter, ATP-binding protein; COG: COG0488; Pfam: PF00005; InterPro: IPR003439. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.721 |
dnaJ | EEX51876.1 | HMPREF6745_2649 | HMPREF6745_2647 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | ABC transporter, ATP-binding protein; COG: COG0488; Pfam: PF00005; InterPro: IPR003439. | 0.715 |
dnaJ | folC | HMPREF6745_2649 | HMPREF6745_2650 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Bifunctional protein FolC; COG: COG0285; Pfam: PF08245; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family. | 0.876 |
dnaJ | galM2 | HMPREF6745_2649 | HMPREF6745_2651 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. | 0.647 |
dnaJ | grpE | HMPREF6745_2649 | HMPREF6745_2648 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.985 |
fhs | folA | HMPREF6745_1060 | HMPREF6745_2313 | Formate--tetrahydrofolate ligase; COG: COG2759; Pfam: PF01268; InterPro: IPR000559; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.855 |
fhs | folC | HMPREF6745_1060 | HMPREF6745_2650 | Formate--tetrahydrofolate ligase; COG: COG2759; Pfam: PF01268; InterPro: IPR000559; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolC; COG: COG0285; Pfam: PF08245; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family. | 0.678 |
fhs | glyA | HMPREF6745_1060 | HMPREF6745_2608 | Formate--tetrahydrofolate ligase; COG: COG2759; Pfam: PF01268; InterPro: IPR000559; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
fhs | thyA | HMPREF6745_1060 | HMPREF6745_2312 | Formate--tetrahydrofolate ligase; COG: COG2759; Pfam: PF01268; InterPro: IPR000559; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.600 |
folA | fhs | HMPREF6745_2313 | HMPREF6745_1060 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate--tetrahydrofolate ligase; COG: COG2759; Pfam: PF01268; InterPro: IPR000559; Belongs to the formate--tetrahydrofolate ligase family. | 0.855 |
folA | folC | HMPREF6745_2313 | HMPREF6745_2650 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional protein FolC; COG: COG0285; Pfam: PF08245; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family. | 0.918 |
folA | folP | HMPREF6745_2313 | HMPREF6745_1618 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; COG: COG0294; Pfam: PF00809; InterPro: IPR000489. | 0.601 |
folA | glyA | HMPREF6745_2313 | HMPREF6745_2608 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.857 |
folA | thyA | HMPREF6745_2313 | HMPREF6745_2312 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
folB | folC | HMPREF6745_0180 | HMPREF6745_2650 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Bifunctional protein FolC; COG: COG0285; Pfam: PF08245; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family. | 0.728 |
folB | folP | HMPREF6745_0180 | HMPREF6745_1618 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; COG: COG0294; Pfam: PF00809; InterPro: IPR000489. | 0.988 |