STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGR_10953Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)    
Predicted Functional Partners:
EGR_10538
Histone H3; Belongs to the histone H3 family.
 
 
 0.901
EGR_02879
RNA polymerase-associated protein LEO1.
    
 
 0.831
EGR_01053
Histone H2B; Belongs to the histone H2B family.
 
 
 0.823
EGR_10952
Histone H2B; Belongs to the histone H2B family.
 
 
 0.823
EGR_06849
Histone H2A; Belongs to the histone H2A family.
 
 
 0.813
EGR_04689
Core histone macro-H2A.1; Belongs to the histone H2A family.
   
 0.808
EGR_07454
Histone H2B; Belongs to the histone H2B family.
 
 
 0.789
EGR_09113
Histone H3-like centromeric protein cnp1.
   
 0.785
EGR_11078
Histone H2B; Belongs to the histone H2B family.
 
 
 0.781
EGR_00518
Histone acetyltransferase KAT2B.
    
 0.778
Your Current Organism:
Echinococcus granulosus
NCBI taxonomy Id: 6210
Other names: E. granulosus, Echinococcus granulosus G1 strain, Echinococcus granulosus G2 strain, Echinococcus granulosus G3 strain, Echinococcus granulosus Tasmanian sheep strain, Echinococcus granulosus buffalo strain, Echinococcus granulosus s. s., Echinococcus granulosus sensu stricto, Echinococcus granulosus sheep strain
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.