STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EmuJ_000822900DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1195 aa)    
Predicted Functional Partners:
EmuJ_000183500
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.998
EmuJ_000761100
DNA mismatch repair protein Mlh1.
 
 0.995
EmuJ_000887200
Mismatch repair endonuclease PMS2.
 
 0.994
A0A068Y9U7
DNA mismatch repair protein MSH2.
  
 0.988
A0A068Y3I2
DNA mismatch repair protein MSH2.
  
0.987
EmuJ_000244900
Exonuclease 1.
  
 0.984
EmuJ_000741400
Fanconi anemia group M protein.
   
 
 0.979
EmuJ_000860550
Hypothetical transcript.
  
 0.957
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 0.946
EmuJ_000714700
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.939
Your Current Organism:
Echinococcus multilocularis
NCBI taxonomy Id: 6211
Other names: E. multilocularis
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