STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
evgAPutative positive transcription regulator (sensor EvgS); Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon (By similarity). (204 aa)    
Predicted Functional Partners:
evgS
Putative sensor for regulator EvgA.
 
 0.999
barA
Sensor-regulator; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay (By similarity).
 
 
 0.967
ydeO
Putative ARAC-type regulatory protein; Induces the expression of gadE. Could also regulate the expression of other genes involved in acid resistance (By similarity).
  
  
 0.775
arcB
Histidine protein kinase/phosphatase, aerobic respiration sensor-response protein, sensor for arcA; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His-717 and Asp-576 (By similarity).
   
 
 0.769
phoP
Transcriptional regulatory protein; Member of the two-component regulatory system PhoQ/PhoP involved in virulence and adaptation to low Mg(2+) environments. Necessary for resistance to killing by polymorphonuclear leukocytes (PMNs) and cationic antimicrobial peptides (CAMP) they produce.
  
 
 
 0.762
phoQ
Sensor protein PhoQ; Member of the two-component regulatory system PhoP/PhoQ involved in virulence and adaptation to low Mg(2+) environments. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, which results in the expression of PhoP- activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, which results in the repression of PAG and may lead to expression of some PRG (B [...]
    
 
 0.761
yhjB
LuxR family transcriptional regulator; Similar to Shigella flexneri conserved hypothetical protein ref: NP_085397.1 (448 aa). BLAST with identity of 77% in 448 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.
  
     0.747
ydeP
Putative oxidoreductase, major subunit; Probably involved in acid resistance; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
      
 0.732
uhpB
Sensor histidine protein kinase, phosphorylates UhpA; Code: T; COG: COG0642.
 
   0.730
csgD
Probable csgAB operon transcriptional regulatory protein; Code: K; COG: COG2771.
  
     0.726
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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