STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nikEATP-binding protein of nickel transport system; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)    
Predicted Functional Partners:
nikB
Transport of nickel, membrane protein; Code: EP; COG: COG0601.
 
 0.999
nikC
Transport of nickel, membrane protein; Code: EP; COG: COG1173.
 
 0.999
nikA
Periplasmic binding protein for nickel; Code: EP; COG: COG0747.
 
 
 0.998
nikD
ATP-binding protein of nickel transport system; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
 
 
0.996
gsiD
Putative transport system permease protein; Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
  
 0.863
yhhG
Conserved hypothetical protein; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel (By similarity).
     
 0.839
oppC
Oligopeptide transport permease protein; Code: EP; COG: COG1173.
  
 0.782
dppC
Dipeptide transport system permease protein 2; Code: EP; COG: COG1173.
  
 0.760
hypF
Transcriptional regulatory protein; Code: O; COG: COG0068.
      
 0.750
hypB
Guanine-nucleotide binding protein; Code: OK; COG: COG0378.
     
 0.733
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.