node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SKB29131.1 | SKB29140.1 | SAMN05660226_00483 | SAMN05660226_00484 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.999 |
SKB29131.1 | SKB29175.1 | SAMN05660226_00483 | SAMN05660226_00489 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.973 |
SKB29131.1 | SKB29178.1 | SAMN05660226_00483 | SAMN05660226_00490 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, large subunit. | 0.940 |
SKB29131.1 | SKB58061.1 | SAMN05660226_00483 | SAMN05660226_02170 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Glutamate synthase (NADPH/NADH) large chain. | 0.412 |
SKB29131.1 | ilvA | SAMN05660226_00483 | SAMN05660226_00481 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.651 |
SKB29131.1 | ilvD | SAMN05660226_00483 | SAMN05660226_00491 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.885 |
SKB29131.1 | leuA | SAMN05660226_00483 | SAMN05660226_00486 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.938 |
SKB29131.1 | leuB | SAMN05660226_00483 | SAMN05660226_00482 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.984 |
SKB29131.1 | leuC | SAMN05660226_00483 | SAMN05660226_00485 | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.998 |
SKB29140.1 | SKB29131.1 | SAMN05660226_00484 | SAMN05660226_00483 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.999 |
SKB29140.1 | SKB29175.1 | SAMN05660226_00484 | SAMN05660226_00489 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | Acetolactate synthase, small subunit. | 0.965 |
SKB29140.1 | SKB29178.1 | SAMN05660226_00484 | SAMN05660226_00490 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | Acetolactate synthase, large subunit. | 0.927 |
SKB29140.1 | SKB40496.1 | SAMN05660226_00484 | SAMN05660226_01219 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | Isocitrate dehydrogenase (NADP). | 0.456 |
SKB29140.1 | SKB58061.1 | SAMN05660226_00484 | SAMN05660226_02170 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | Glutamate synthase (NADPH/NADH) large chain. | 0.587 |
SKB29140.1 | ilvA | SAMN05660226_00484 | SAMN05660226_00481 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.883 |
SKB29140.1 | ilvD | SAMN05660226_00484 | SAMN05660226_00491 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.945 |
SKB29140.1 | leuA | SAMN05660226_00484 | SAMN05660226_00486 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.998 |
SKB29140.1 | leuB | SAMN05660226_00484 | SAMN05660226_00482 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.999 |
SKB29140.1 | leuC | SAMN05660226_00484 | SAMN05660226_00485 | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
SKB29175.1 | SKB29131.1 | SAMN05660226_00489 | SAMN05660226_00483 | Acetolactate synthase, small subunit. | D-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.973 |