STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zyg-1Probable serine/threonine-protein kinase zyg-1; Protein kinase that plays a central role in centrosome duplication. Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization. Maternal copy regulates centrosome duplication during later cell cycles. Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome (By similarity). (709 aa)    
Predicted Functional Partners:
sas-5
Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis (By similarity).
    
 
 0.988
sas-4
Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size (By similarity).
   
 
 0.976
spd-2
Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment.
   
 
 0.962
sas-6
Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication (By similarity).
   
 0.939
plk-1
Serine/threonine-protein kinase PLK.
  
0.924
plk-2
Serine/threonine-protein kinase PLK.
  
0.915
sas-7
Protein CBG24610.
   
 0.865
szy-20
Protein CBR-SZY-20.
   
 
 0.843
spd-5
Protein CBR-SPD-5.
    
 
 0.816
mdf-1
Protein CBR-MDF-1.
   
 
 0.663
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.