STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unc-64Syntaxin-1A; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent s [...] (293 aa)    
Predicted Functional Partners:
unc-18
Protein CBR-UNC-18; Belongs to the STXBP/unc-18/SEC1 family.
   
 0.999
snb-1
Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function (By similarity).
    
 0.999
Cbr-snb-7
Protein CBR-SNB-7.
   
 0.997
ric-4
Synaptosomal-associated protein; Belongs to the SNAP-25 family.
   
 0.993
snap-1
Protein CBR-SNAP-1.
   
 0.991
snt-1
Protein CBR-SNT-1.
   
 0.979
CBG13544
Protein CBG13544; Belongs to the STXBP/unc-18/SEC1 family.
   
 0.975
unc-10
Protein CBR-UNC-10.
   
 
 0.968
sri-18
Protein CBR-SRI-18.
   
 0.959
tom-1
Protein CBR-TOM-1.
    
 0.955
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.