STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
png-1Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...] (602 aa)    
Predicted Functional Partners:
rps-30
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
 0.996
ubl-1
Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family.
   
 0.954
ubq-1
Protein CBR-UBQ-1.
   
 0.951
ubql-1
Protein CBG10788.
   
 0.951
ned-8
Protein CBR-NED-8.
   
 0.951
CBG19642
Protein CBG19642.
   
 0.951
CBG21708
Protein CBG21708.
   
 0.951
CBG00586
Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.
   
 0.947
cup-2
Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.
   
 0.947
rpt-2
Protein CBR-RPT-2; Belongs to the AAA ATPase family.
   
 0.937
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.