STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spk-1Serine/threonine-protein kinase spk-1; Required for embryogenesis and germline development in both adult hermaphrodites and males. SR-protein kinase (SRPK) that binds directly to and phosphorylates RS domains (By similarity). (1132 aa)    
Predicted Functional Partners:
lag-1
Protein CBR-LAG-1.
   
 
 0.910
CBG06864
Protein CBG06864.
      
 0.743
rsp-3
Protein CBR-RSP-3.
    
 
 0.664
rhgf-1
Protein CBR-RHGF-1.
      
 0.630
abl-1
Tyrosine-protein kinase.
    
 
 0.559
uaf-1
Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).
    
 
 0.538
CBG20414
Protein CBG20414.
    
 
 0.525
cdc-5l
Protein CBG12532.
    
   0.499
smg-1
Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2 (By similarity); Belongs to the PI3/PI4-kinase family.
   
 
 0.495
glp-1
Protein CBR-GLP-1.
    
 
 0.487
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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