STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lin-14Protein lin-14; Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin- like growth factor gene ins-33. (543 aa)    
Predicted Functional Partners:
lin-28
Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis (By similarity); Belongs to the lin-28 family.
      
 0.954
lin-41
Protein CBR-LIN-41.
      
 0.911
hbl-1
Protein CBR-HBL-1.
      
 0.872
lin-29
Protein CBR-LIN-29.
      
 0.828
lin-42
Protein CBR-LIN-42.1.
      
 0.805
daf-12
Protein CBR-DAF-12.
      
 0.754
lin-46
Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
      
 0.724
ain-1
Protein CBR-AIN-1.
      
 0.649
drsh-1
Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA (By similarity). Belongs to the ribonuclease III family.
      
 0.644
oig-1
Protein CBR-OIG-1.
      
 0.643
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.