node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
atx-3 | cdc-48.1 | Q60XN1 | A8WSV1 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Protein CBG03070; Belongs to the AAA ATPase family. | 0.971 |
atx-3 | cdc-48.2 | Q60XN1 | A8WN57 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Protein CBG00746; Belongs to the AAA ATPase family. | 0.943 |
atx-3 | cdc-48.3 | Q60XN1 | A8X627 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Protein CBR-CDC-48.3. | 0.859 |
atx-3 | daf-16 | Q60XN1 | A8XFP9 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Protein CBR-DAF-16. | 0.934 |
atx-3 | josd-1 | Q60XN1 | A8WMS1 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Protein CBG00486. | 0.949 |
atx-3 | pdr-1 | Q60XN1 | A8XSA1 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.990 |
atx-3 | ubl-1 | Q60XN1 | P37164 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family. | 0.901 |
atx-3 | ubq-1 | Q60XN1 | A8X7Y8 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Protein CBR-UBQ-1. | 0.890 |
atx-3 | ufd-2 | Q60XN1 | A8XI03 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Protein CBR-UFD-2. | 0.738 |
atx-3 | usp-14 | Q60XN1 | A8WP63 | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | Ubiquitin carboxyl-terminal hydrolase. | 0.777 |
cdc-48.1 | atx-3 | A8WSV1 | Q60XN1 | Protein CBG03070; Belongs to the AAA ATPase family. | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | 0.971 |
cdc-48.1 | cdc-48.2 | A8WSV1 | A8WN57 | Protein CBG03070; Belongs to the AAA ATPase family. | Protein CBG00746; Belongs to the AAA ATPase family. | 0.998 |
cdc-48.1 | cdc-48.3 | A8WSV1 | A8X627 | Protein CBG03070; Belongs to the AAA ATPase family. | Protein CBR-CDC-48.3. | 0.915 |
cdc-48.1 | pdr-1 | A8WSV1 | A8XSA1 | Protein CBG03070; Belongs to the AAA ATPase family. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.435 |
cdc-48.1 | ubl-1 | A8WSV1 | P37164 | Protein CBG03070; Belongs to the AAA ATPase family. | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the N-terminal section; belongs to the ubiquitin family. | 0.745 |
cdc-48.1 | ubq-1 | A8WSV1 | A8X7Y8 | Protein CBG03070; Belongs to the AAA ATPase family. | Protein CBR-UBQ-1. | 0.877 |
cdc-48.1 | ufd-2 | A8WSV1 | A8XI03 | Protein CBG03070; Belongs to the AAA ATPase family. | Protein CBR-UFD-2. | 0.898 |
cdc-48.1 | usp-14 | A8WSV1 | A8WP63 | Protein CBG03070; Belongs to the AAA ATPase family. | Ubiquitin carboxyl-terminal hydrolase. | 0.448 |
cdc-48.2 | atx-3 | A8WN57 | Q60XN1 | Protein CBG00746; Belongs to the AAA ATPase family. | Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a [...] | 0.943 |
cdc-48.2 | cdc-48.1 | A8WN57 | A8WSV1 | Protein CBG00746; Belongs to the AAA ATPase family. | Protein CBG03070; Belongs to the AAA ATPase family. | 0.998 |