STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gsnl-1Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. (474 aa)    
Predicted Functional Partners:
act-5
Protein CBR-ACT-5.
    
 
 0.999
cogc-8
Protein CBR-COGC-8.
    
 
 0.867
viln-1
Protein CBG03958.
    
 
 0.858
cogc-3
Protein CBR-COGC-3.
    
 
 0.820
cogc-4
Protein CBR-COGC-4.
    
 
 0.810
twf-2
Protein CBG16364.
   
 0.795
lin-2
Protein CBR-LIN-2; Belongs to the MAGUK family.
    
 0.793
pfn-3
Profilin; Belongs to the profilin family.
   
 
 0.770
CBG14672
Profilin; Belongs to the profilin family.
   
 
 0.759
ced-3
Protein CBR-CED-3; Belongs to the peptidase C14A family.
    
 0.755
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.