STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hst-1Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (By similarity); Belongs to the sulfotransferase 1 family. NDST subfamily. (859 aa)    
Predicted Functional Partners:
hse-5
Protein CBR-HSE-5.
   
 0.980
hst-6
Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
      
 0.838
hst-2
Protein CBR-HST-2.
   
 
 0.806
rib-1
Protein CBR-RIB-1; Belongs to the glycosyltransferase 47 family.
   
  
 0.701
sdn-1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
     
 0.674
rib-2
Protein CBR-RIB-2; Belongs to the glycosyltransferase 47 family.
   
  
 0.640
cle-1
Protein CBR-CLE-1, isoform b.
      
 0.632
CBG19078
Protein CBG19078.
     
 0.590
CBG23225
Protein CBG23225.
    
 
 0.566
nlp-66
Protein CBG17432.
      
 0.531
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.