STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xrn-25'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle. (976 aa)    
Predicted Functional Partners:
paxt-1
Protein CBG12509.
    
 
 0.998
cids-1
CID domain-containing protein 1.
   
 
 0.915
dyf-19
Protein CBG05687.
   
 
 0.915
cids-2
Protein CBR-CIDS-2.
   
 
 0.857
xrn-1
5'-3' exoribonuclease 1.
  
 
 
0.849
CBG11415
Protein CBG11415.
   
 
 0.783
eol-1
Protein CBG11414.
   
 
 0.783
CBG11412
Protein CBG11412.
   
 
 0.783
CBG11411
Protein CBG11411.
   
 
 0.783
dcs-1
Protein CBR-DCS-1.
   
  
 0.751
Your Current Organism:
Caenorhabditis briggsae
NCBI taxonomy Id: 6238
Other names: C. briggsae, Caenorhabditis briggsae AF16
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.