node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBG05718 | CBG14916 | A8X1T4 | A8XKZ6 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Protein CBG14916. | 0.654 |
CBG05718 | CBG23625 | A8X1T4 | A8WIY8 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.924 |
CBG05718 | adss-1 | A8X1T4 | A8X7H5 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. | 0.989 |
CBG05718 | ampd-1 | A8X1T4 | A8WUJ0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Protein CBG02349. | 0.969 |
CBG05718 | cat-4 | A8X1T4 | A8X8K8 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Protein CBR-CAT-4. | 0.522 |
CBG05718 | dut-1 | A8X1T4 | A8WWK0 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Protein CBR-DUT-1. | 0.408 |
CBG05718 | gmps-1 | A8X1T4 | A8WT10 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Protein CBG03001. | 0.999 |
CBG05718 | guk-1 | A8X1T4 | A8XEQ3 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Protein CBR-GUK-1. | 0.553 |
CBG05718 | hap-1 | A8X1T4 | A8XZP2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.955 |
CBG05718 | ndk-1 | A8X1T4 | A8WS68 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Nucleoside diphosphate kinase. | 0.408 |
CBG14916 | CBG05718 | A8XKZ6 | A8X1T4 | Protein CBG14916. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.654 |
CBG14916 | CBG23625 | A8XKZ6 | A8WIY8 | Protein CBG14916. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.958 |
CBG14916 | adss-1 | A8XKZ6 | A8X7H5 | Protein CBG14916. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. | 0.780 |
CBG14916 | ampd-1 | A8XKZ6 | A8WUJ0 | Protein CBG14916. | Protein CBG02349. | 0.991 |
CBG14916 | cat-4 | A8XKZ6 | A8X8K8 | Protein CBG14916. | Protein CBR-CAT-4. | 0.532 |
CBG14916 | dut-1 | A8XKZ6 | A8WWK0 | Protein CBG14916. | Protein CBR-DUT-1. | 0.606 |
CBG14916 | gmps-1 | A8XKZ6 | A8WT10 | Protein CBG14916. | Protein CBG03001. | 0.992 |
CBG14916 | guk-1 | A8XKZ6 | A8XEQ3 | Protein CBG14916. | Protein CBR-GUK-1. | 0.974 |
CBG14916 | hap-1 | A8XKZ6 | A8XZP2 | Protein CBG14916. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.988 |
CBG14916 | ndk-1 | A8XKZ6 | A8WS68 | Protein CBG14916. | Nucleoside diphosphate kinase. | 0.551 |