Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cki-1 | lin-35 | T05A6.1.1 | C32F10.2.1 | Cyclin-dependent kinase inhibitor 1; Negative cell-cycle regulator that functions at the G1-to-S- phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa. Belongs to the CDI family. | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.942 |
| cki-1 | xnp-1 | T05A6.1.1 | B0041.7.2 | Cyclin-dependent kinase inhibitor 1; Negative cell-cycle regulator that functions at the G1-to-S- phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa. Belongs to the CDI family. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.685 |
| hira-1 | lin-35 | K10D2.1a.1 | C32F10.2.1 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.578 |
| hira-1 | pqn-80 | K10D2.1a.1 | Y111B2A.14c.1 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | HUN domain-containing protein. | 0.935 |
| hira-1 | xnp-1 | K10D2.1a.1 | B0041.7.2 | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.731 |
| lin-35 | cki-1 | C32F10.2.1 | T05A6.1.1 | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | Cyclin-dependent kinase inhibitor 1; Negative cell-cycle regulator that functions at the G1-to-S- phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa. Belongs to the CDI family. | 0.942 |
| lin-35 | hira-1 | C32F10.2.1 | K10D2.1a.1 | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | 0.578 |
| lin-35 | slr-2 | C32F10.2.1 | Y59A8B.13a.1 | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | Synthetic with Lin-35/Rb. | 0.430 |
| lin-35 | spr-1 | C32F10.2.1 | D1014.8.1 | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. | 0.468 |
| lin-35 | xnp-1 | C32F10.2.1 | B0041.7.2 | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.725 |
| nurf-1 | xnp-1 | F26H11.2a.1 | B0041.7.2 | Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.663 |
| pqn-80 | hira-1 | Y111B2A.14c.1 | K10D2.1a.1 | HUN domain-containing protein. | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. | 0.935 |
| pqn-80 | xnp-1 | Y111B2A.14c.1 | B0041.7.2 | HUN domain-containing protein. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.895 |
| rad-51 | xnp-1 | Y43C5A.6a.1 | B0041.7.2 | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.915 |
| rbm-25 | thoc-2 | W04D2.6c.2 | C16A3.8.1 | PWI domain-containing protein. | THO Complex (Transcription factor/nuclear export) subunit. | 0.487 |
| rbm-25 | xnp-1 | W04D2.6c.2 | B0041.7.2 | PWI domain-containing protein. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.634 |
| slr-2 | lin-35 | Y59A8B.13a.1 | C32F10.2.1 | Synthetic with Lin-35/Rb. | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.430 |
| slr-2 | xnp-1 | Y59A8B.13a.1 | B0041.7.2 | Synthetic with Lin-35/Rb. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.641 |
| spr-1 | lin-35 | D1014.8.1 | C32F10.2.1 | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] | 0.468 |
| spr-1 | xnp-1 | D1014.8.1 | B0041.7.2 | REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. | Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development. | 0.643 |
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