STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hlh-1Myoblast determination protein 1 homolog; Accumulation defines the body wall muscle cell fate during embryogenesis. Acts redundantly with fozi-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2. (324 aa)    
Predicted Functional Partners:
hlh-2
BHLH domain-containing protein.
   
 
 0.887
gdi-1
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
      
 0.697
K09B3.1
ShKT domain-containing protein.
   
  
 0.692
nhr-277
Nuclear Hormone Receptor family.
      
 0.692
F26A1.1
Uncharacterized protein.
      
 0.691
dyb-1
Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.
   
  
 0.671
H01M10.2
Uncharacterized protein.
      
 0.621
unc-120
MADS-box domain-containing protein.
   
 
 0.614
pcaf-1
P300/CBP Associated Factor homolog.
    
 
 0.573
aha-1
Aryl hydrocarbon receptor nuclear translocator homolog; Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons.
   
 
 0.572
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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