STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bre-3Beta-1,4-mannosyltransferase bre-3; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre- 1, bre-2, bre-4 and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. Has a role in determining brood size. (455 aa)    
Predicted Functional Partners:
bre-4
Beta-1,4-N-acetylgalactosaminyltransferase bre-4; Catalyzes the transfer of galactose onto proteins or lipids. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3 and bre-5. Belongs to the glycosyltransferase 7 family.
   
  
 0.919
bre-2
Beta-1,3-galactosyltransferase bre-2; Transfers N-acetylgalactosamine onto carbohydrate substrates (By similarity). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.
      
 0.916
bre-5
Beta-1,3-galactosyltransferase bre-5; Transfers N-acetylgalactosamine onto mannose groups of carbohydrate substrates. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3, and bre-4. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.
      
 0.914
cgt-1
Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family.
     
 0.740
agxt-1
Serine--pyruvate aminotransferase.
    
 0.724
F08A8.5
Galactoside 2-alpha-L-fucosyltransferase; Selectively catalyzes the addition of fucose in alpha 1-2 linkage to Gal-beta-(1->3)-GalNAc-alpha-R, Gal-beta-(1->3)-(GlcNAc- beta-(1->6))-GalNAc-alpha-R and Gal-beta-(1->3)-GalNAc acceptors but not Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta-(1->4)-Glc in vitro.
     
 0.704
cgt-2
Ceramide glucosyltransferase 2; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family.
     
 0.702
galt-1
Beta-1,4-galactosyltransferase galt-1; Catalyzes the transfer of beta-galactose from UDP-galactose to position 4 of alpha-1,6-linked fucose at the reducing end GlcNAc in N-glycan cores. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds.
     
 0.696
F35E12.10
CUB_2 domain-containing protein.
      
 0.693
pygl-1
Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 
 0.690
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.