STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdk-11.1Cyclin-dependent kinase 11.1; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Important for normal oocyte and sperm development; probably required during multiple stages of gametogenesis. Plays a role in the activation of RAS-ERK signaling in the germ line. Also acts partially redundantly with cdk-11.2 to ensure embryonic viability. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (719 aa)    
Predicted Functional Partners:
cyl-1
Cyclin L; Belongs to the cyclin family.
   
 
 0.906
C24A1.3
Uncharacterized protein.
      
 0.850
hpo-11
Protein kinase domain-containing protein.
      
 0.808
Y47G6A.13
Protein kinase domain-containing protein.
      
 0.669
efk-1
Eukaryotic elongation factor 2 kinase; Phosphorylates 2 adjacent threonine residues, 'Thr-57' and 'Thr-59', in the N-terminus of eukaryotic elongation factor-2.
      
 0.660
sin-3
Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC).
   
    0.548
prp-3
Yeast PRP (Splicing factor) related.
   
  
 0.519
prpf-4
Protein kinase domain-containing protein.
   
   
0.465
skih-2
SKI (Yeast SuperKIller) Helicase homolog.
   
    0.461
ccnk-1
CYCLIN domain-containing protein; Belongs to the cyclin family.
   
 
 0.443
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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