STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C01B10.8Methyltranfer_dom domain-containing protein. (656 aa)    
Predicted Functional Partners:
atat-2
Alpha-tubulin N-acetyltransferase 2; Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act [...]
    
 
 0.915
rgs-5
Regulator of G-protein signaling rgs-5.
      
 0.892
swsn-1
SANT domain-containing protein.
    
 
 0.715
amph-1
AMPHiphysin homolog.
      
 0.660
C23G10.7
Probable tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Belongs to the TRM44 family.
   
  
 0.572
K08E4.6
GOLD domain-containing protein.
   
  
 0.563
T20D3.8
PhosphatidylInositol Glycan anchor biosynthesis class C.
   
  
 0.552
ran-3
Regulator of chromosome condensation; Key component of the Ran GTPase system, which comprises ran- 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
   
  
 0.532
C01B10.9
Uncharacterized protein.
 
 
    0.520
T03G11.6
MEthylTransferase Like.
   
  
 0.510
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.