node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ercc-1 | fan-1 | F10G8.7.2 | C01G5.8a.1 | ERCC (DNA excision repair protein) homolog. | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | 0.858 |
ercc-1 | fcd-2 | F10G8.7.2 | Y41E3.9a.1 | ERCC (DNA excision repair protein) homolog. | FANCD2 (Fanconi's anemia defect) ortholog. | 0.869 |
ercc-1 | fnci-1 | F10G8.7.2 | W02D3.10.1 | ERCC (DNA excision repair protein) homolog. | FANCI_HD2 domain-containing protein. | 0.668 |
ercc-1 | mlh-1 | F10G8.7.2 | T28A8.7.1 | ERCC (DNA excision repair protein) homolog. | DNA_mis_repair domain-containing protein. | 0.909 |
ercc-1 | mus-81 | F10G8.7.2 | C43E11.2a.1 | ERCC (DNA excision repair protein) homolog. | ERCC4 domain-containing protein. | 0.997 |
ercc-1 | pms-2 | F10G8.7.2 | H12C20.2a.1 | ERCC (DNA excision repair protein) homolog. | PMS (Post Meiotic Segregation) family. | 0.846 |
ercc-1 | polk-1 | F10G8.7.2 | F22B7.6a.1 | ERCC (DNA excision repair protein) homolog. | DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Belongs to the DNA polymerase type-Y family. | 0.673 |
ercc-1 | slx-1 | F10G8.7.2 | F56A3.2.1 | ERCC (DNA excision repair protein) homolog. | Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] | 0.987 |
ercc-1 | wrn-1 | F10G8.7.2 | F18C5.2.1 | ERCC (DNA excision repair protein) homolog. | Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity). | 0.593 |
ercc-1 | xpf-1 | F10G8.7.2 | C47D12.8.1 | ERCC (DNA excision repair protein) homolog. | ERCC4 domain-containing protein. | 0.999 |
fan-1 | ercc-1 | C01G5.8a.1 | F10G8.7.2 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | ERCC (DNA excision repair protein) homolog. | 0.858 |
fan-1 | fcd-2 | C01G5.8a.1 | Y41E3.9a.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | FANCD2 (Fanconi's anemia defect) ortholog. | 0.998 |
fan-1 | fnci-1 | C01G5.8a.1 | W02D3.10.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | FANCI_HD2 domain-containing protein. | 0.904 |
fan-1 | mlh-1 | C01G5.8a.1 | T28A8.7.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | DNA_mis_repair domain-containing protein. | 0.993 |
fan-1 | mus-81 | C01G5.8a.1 | C43E11.2a.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | ERCC4 domain-containing protein. | 0.931 |
fan-1 | pms-2 | C01G5.8a.1 | H12C20.2a.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | PMS (Post Meiotic Segregation) family. | 0.966 |
fan-1 | polk-1 | C01G5.8a.1 | F22B7.6a.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Belongs to the DNA polymerase type-Y family. | 0.851 |
fan-1 | slx-1 | C01G5.8a.1 | F56A3.2.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] | 0.892 |
fan-1 | wrn-1 | C01G5.8a.1 | F18C5.2.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity). | 0.846 |
fan-1 | xpf-1 | C01G5.8a.1 | C47D12.8.1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. | ERCC4 domain-containing protein. | 0.903 |