STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
henn-1Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...] (442 aa)    
Predicted Functional Partners:
parn-1
3'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro.
   
  
 0.908
ergo-1
Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...]
   
  
 0.868
prg-1
Piwi-like protein; Belongs to the argonaute family.
   
 
 0.857
alg-3
Argonaute (Plant)-Like protein.
      
 0.825
hrde-1
Uncharacterized protein C16C10.3.
   
  
 0.787
tofu-1
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
  
 0.775
tofu-7
Twenty One u-rna (21U-RNA) biogenesis Fouled Up.
   
  
 0.761
fbxc-39
F-box C protein.
      
 0.758
clec-238
C-type lectin domain-containing protein.
      
 0.758
ZK1320.5
Uncharacterized protein ZK1320.5.
      
 0.758
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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