node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y105E8A.1 | ikb-1 | Y105E8A.1b.1 | C04F12.3.1 | Glutaredoxin domain-containing protein. | ANK_REP_REGION domain-containing protein. | 0.623 |
Y105E8A.1 | set-29 | Y105E8A.1b.1 | Y92H12BR.6.1 | Glutaredoxin domain-containing protein. | SET domain-containing protein. | 0.808 |
apl-1 | ikb-1 | C42D8.8a.1 | C04F12.3.1 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | ANK_REP_REGION domain-containing protein. | 0.704 |
ikb-1 | Y105E8A.1 | C04F12.3.1 | Y105E8A.1b.1 | ANK_REP_REGION domain-containing protein. | Glutaredoxin domain-containing protein. | 0.623 |
ikb-1 | apl-1 | C04F12.3.1 | C42D8.8a.1 | ANK_REP_REGION domain-containing protein. | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] | 0.704 |
ikb-1 | malt-1 | C04F12.3.1 | F22D3.6.1 | ANK_REP_REGION domain-containing protein. | MALT1 paracaspase homolog. | 0.640 |
ikb-1 | ned-8 | C04F12.3.1 | F45H11.2.1 | ANK_REP_REGION domain-containing protein. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.618 |
ikb-1 | pik-1 | C04F12.3.1 | K09B11.1a.2 | ANK_REP_REGION domain-containing protein. | Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | 0.923 |
ikb-1 | prk-2 | C04F12.3.1 | F45H7.4.2 | ANK_REP_REGION domain-containing protein. | Serine/threonine-protein kinase prk-2; Involved in the negative regulation of synaptic differentiation in PLM neurons; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. PIM subfamily. | 0.652 |
ikb-1 | set-29 | C04F12.3.1 | Y92H12BR.6.1 | ANK_REP_REGION domain-containing protein. | SET domain-containing protein. | 0.618 |
ikb-1 | tol-1 | C04F12.3.1 | C07F11.1.1 | ANK_REP_REGION domain-containing protein. | TIR domain-containing protein. | 0.909 |
ikb-1 | trf-1 | C04F12.3.1 | F45G2.6.1 | ANK_REP_REGION domain-containing protein. | TNF Receptor Associated Factor (TRAF) homolog. | 0.912 |
ikb-1 | ubq-2 | C04F12.3.1 | ZK1010.1.1 | ANK_REP_REGION domain-containing protein. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.645 |
malt-1 | ikb-1 | F22D3.6.1 | C04F12.3.1 | MALT1 paracaspase homolog. | ANK_REP_REGION domain-containing protein. | 0.640 |
ned-8 | ikb-1 | F45H11.2.1 | C04F12.3.1 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | ANK_REP_REGION domain-containing protein. | 0.618 |
ned-8 | ubq-2 | F45H11.2.1 | ZK1010.1.1 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.940 |
pik-1 | ikb-1 | K09B11.1a.2 | C04F12.3.1 | Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | ANK_REP_REGION domain-containing protein. | 0.923 |
pik-1 | tol-1 | K09B11.1a.2 | C07F11.1.1 | Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | TIR domain-containing protein. | 0.919 |
pik-1 | trf-1 | K09B11.1a.2 | F45G2.6.1 | Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. | TNF Receptor Associated Factor (TRAF) homolog. | 0.904 |
prk-2 | ikb-1 | F45H7.4.2 | C04F12.3.1 | Serine/threonine-protein kinase prk-2; Involved in the negative regulation of synaptic differentiation in PLM neurons; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. PIM subfamily. | ANK_REP_REGION domain-containing protein. | 0.652 |