STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cls-1Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (By similarity). Operates redundantly with cls-2 and cls-3 in regulating microtubule processes which position the spindle during asymmetric cell division. (1378 aa)    
Predicted Functional Partners:
klp-13
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
    
 
 0.856
ebp-2
Microtubule End Binding Protein.
    
 
 0.767
Y59E9AL.6
Uncharacterized protein.
      
 0.758
C41G7.6
Uncharacterized protein.
      
 0.741
klp-7
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.688
zyg-9
Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes.
   
 
 0.511
unc-116
Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites.
   
 
 0.460
dhc-1
Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells. May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron. This function may involve the regulation of dynein by pct-1 and/or cdk-5. Involved in the formation of synapses in the dorsal regi [...]
   
 
 0.442
dhc-3
Dynein Heavy Chain.
    
 
 0.400
dhc-4
DHC_N2 domain-containing protein.
    
 
 0.400
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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