node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cir-1 | ctbp-1 | F55F8.4.2 | F49E10.5a.1 | Cir_N domain-containing protein. | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | 0.713 |
cir-1 | gei-8 | F55F8.4.2 | C14B9.6a.3 | Cir_N domain-containing protein. | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | 0.438 |
cir-1 | hda-1 | F55F8.4.2 | C53A5.3.1 | Cir_N domain-containing protein. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | 0.833 |
cir-1 | hda-2 | F55F8.4.2 | C08B11.2.1 | Cir_N domain-containing protein. | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] | 0.842 |
cir-1 | hda-3 | F55F8.4.2 | R06C1.1.1 | Cir_N domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.838 |
cir-1 | lag-1 | F55F8.4.2 | K08B4.1d.1 | Cir_N domain-containing protein. | Lin-12 And Glp-1 phenotype. | 0.962 |
cir-1 | rba-1 | F55F8.4.2 | K07A1.11.1 | Cir_N domain-containing protein. | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. | 0.548 |
ctbp-1 | cir-1 | F49E10.5a.1 | F55F8.4.2 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Cir_N domain-containing protein. | 0.713 |
ctbp-1 | gei-8 | F49E10.5a.1 | C14B9.6a.3 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | 0.772 |
ctbp-1 | hda-1 | F49E10.5a.1 | C53A5.3.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | 0.892 |
ctbp-1 | hda-2 | F49E10.5a.1 | C08B11.2.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] | 0.892 |
ctbp-1 | hda-3 | F49E10.5a.1 | R06C1.1.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.892 |
ctbp-1 | lag-1 | F49E10.5a.1 | K08B4.1d.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Lin-12 And Glp-1 phenotype. | 0.960 |
gei-8 | cir-1 | C14B9.6a.3 | F55F8.4.2 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | Cir_N domain-containing protein. | 0.438 |
gei-8 | ctbp-1 | C14B9.6a.3 | F49E10.5a.1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | 0.772 |
gei-8 | hda-1 | C14B9.6a.3 | C53A5.3.1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | 0.839 |
gei-8 | hda-2 | C14B9.6a.3 | C08B11.2.1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...] | 0.955 |
gei-8 | hda-3 | C14B9.6a.3 | R06C1.1.1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.764 |
gei-8 | lag-1 | C14B9.6a.3 | K08B4.1d.1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | Lin-12 And Glp-1 phenotype. | 0.555 |
gei-8 | pcaf-1 | C14B9.6a.3 | Y47G6A.6.1 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. | P300/CBP Associated Factor homolog. | 0.962 |