STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cgef-1DH domain-containing protein. (1055 aa)    
Predicted Functional Partners:
Y95B8A.12
Pleckstrin homology and RHoGef (RhoGEF) domain containing.
      
 0.817
rga-4
Rho-GAP domain-containing protein.
      
 0.741
osg-1
Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress.
   
  
 0.732
rga-8
Rho-GAP domain-containing protein.
   
  
 0.716
tag-52
Putative protein tag-52.
   
  
 0.711
Y37A1B.17
Uncharacterized protein.
   
  
 0.708
cdc-42
Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...]
   
 
 0.705
rga-9
Rho-GAP domain-containing protein.
      
 0.698
F22G12.5
DHR-2 domain-containing protein; Belongs to the DOCK family.
   
  
 0.696
BE0003N10.1
S1 motif domain-containing protein.
   
  
 0.695
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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