node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ZK430.5 | air-1 | ZK430.5.1 | K07C11.2.2 | Peptidase C50 domain-containing protein. | Protein kinase domain-containing protein. | 0.644 |
ZK430.5 | cdc-14 | ZK430.5.1 | C17G10.4h.1 | Peptidase C50 domain-containing protein. | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | 0.893 |
ZK430.5 | cyb-2.1 | ZK430.5.1 | Y43E12A.1.1 | Peptidase C50 domain-containing protein. | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | 0.979 |
ZK430.5 | cyb-2.2 | ZK430.5.1 | H31G24.4.2 | Peptidase C50 domain-containing protein. | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | 0.979 |
ZK430.5 | icp-1 | ZK430.5.1 | Y39G10AR.13a.2 | Peptidase C50 domain-containing protein. | INCENP_ARK-bind domain-containing protein. | 0.698 |
ZK430.5 | plk-1 | ZK430.5.1 | C14B9.4b.1 | Peptidase C50 domain-containing protein. | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | 0.981 |
ZK430.5 | zen-4 | ZK430.5.1 | M03D4.1d.2 | Peptidase C50 domain-containing protein. | Kinesin-like protein. | 0.729 |
air-1 | ZK430.5 | K07C11.2.2 | ZK430.5.1 | Protein kinase domain-containing protein. | Peptidase C50 domain-containing protein. | 0.644 |
air-1 | cdc-14 | K07C11.2.2 | C17G10.4h.1 | Protein kinase domain-containing protein. | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | 0.602 |
air-1 | cyb-2.1 | K07C11.2.2 | Y43E12A.1.1 | Protein kinase domain-containing protein. | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | 0.838 |
air-1 | cyb-2.2 | K07C11.2.2 | H31G24.4.2 | Protein kinase domain-containing protein. | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | 0.818 |
air-1 | icp-1 | K07C11.2.2 | Y39G10AR.13a.2 | Protein kinase domain-containing protein. | INCENP_ARK-bind domain-containing protein. | 0.983 |
air-1 | plk-1 | K07C11.2.2 | C14B9.4b.1 | Protein kinase domain-containing protein. | Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] | 0.954 |
air-1 | sep-1 | K07C11.2.2 | Y47G6A.12.2 | Protein kinase domain-containing protein. | Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] | 0.673 |
air-1 | spd-2 | K07C11.2.2 | F32H2.3.1 | Protein kinase domain-containing protein. | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.845 |
air-1 | spd-5 | K07C11.2.2 | F56A3.4.1 | Protein kinase domain-containing protein. | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.914 |
air-1 | zen-4 | K07C11.2.2 | M03D4.1d.2 | Protein kinase domain-containing protein. | Kinesin-like protein. | 0.796 |
cdc-14 | ZK430.5 | C17G10.4h.1 | ZK430.5.1 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | Peptidase C50 domain-containing protein. | 0.893 |
cdc-14 | air-1 | C17G10.4h.1 | K07C11.2.2 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | Protein kinase domain-containing protein. | 0.602 |
cdc-14 | cyb-2.1 | C17G10.4h.1 | Y43E12A.1.1 | Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and [...] | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. | 0.868 |